Epilepsy is a chronic neurological disorder that causes abnormal brain function due to the characteristic of seizures. Seizures produce large amounts of oxidative stress. Oxidative stress causes damage to brain cells. Glutathione is a neuromodulator, meaning it affects the function of brain cells. Glutathione can help prevent seizures and the effects of anticonvulsants. Anticonvulsants can lower the levels of glutathione within the brain, which allows for more oxidative stress.

http://www.ncbi.nlm.nih.gov/pubmed/?term=10876010