Bipolar Disorder is associated with oxidative stress. Bipolar Disorder creates alterations in dopamine and glutamate, which are highly redox reactive. When both dopamine and glutamate are altered there is an increase in oxygen to the brain. Glutathione and other antioxidants are being researched further for a treatment, but an antioxidant precursor treatment is effective.

http://www.ncbi.nlm.nih.gov/pubmed/19689277