Glutathione411 » Age Related

How Glutathione May Help Rheumatoid Arthritis

dataEntry — Thu, 30 Oct 2014 03:53:54 +0000

Rheumatoid Arthritis is an inflammatory disease that affects the lining of the joints, which produces joint inflammation. Glutathione may help control the disease and alleviate the symptoms. Rheumatoid Arthritis progresses with age; glutathione neutralizes free radicals, which lessens the damage to the muscles and tissues of the joints. Glutathione is anti-inflammatory meaning it will help control... Read more »

Age-related Decline in Immunity

dataEntry — Thu, 30 Oct 2014 02:50:12 +0000

Studies have shown that levels of GSH in the blood decrease with age. GSH functions as an antioxidant along with vitamins C and E to reduce levels of toxins in the blood and tissues. As we age, the levels of GSH decrease along with our ability to fight the diseases associated with aging. The attack of the toxins is often called “oxidative stress” and the lower levels of GSH in the blood and tissue reduce our ability to compensate for exposure to the free radicals. This decline is also associated with age related macular degeneration and diabetes. The generalized oxidation associated with aging may contribute to the development of age-related toxicities and pathology.

GSH serves several physiological functions. It quenches free radicals through direct interaction, helps to degrade harmful peroxides, and acts as a coenzyme. The main relevance of GSH to the aging process is that it provides important defense against oxidative stress, namely the reduction of hydrogen peroxide and lipid peroxides. GSH has the dual ability to quench free radical as well as donate electrons to essential cellular functions. It is regarded as the single most versatile antioxidant in cells with broad effects on antioxidant potential. It also maintains a buffer that is critical in most cellular processes including division and protein structure. An age-related loss of GSH can be predicted to have at least two dire consequences. One is the increase of levels of hydrogen peroxide and the second is the formation of molecules that interfere with enzymes in the body. This reduces the body’s ability to adapt under stress. Maintenance of optimal GSH levels in essential for limiting oxidative damage.

Wrinkles are a side effect of aging. Glutathione is a critical component for the body’s defense system. Glutathione provides protection for the cells against stress. Mild effects of stress stimulate glutathione levels, which increases the protection against more severe stress. Aging causes decreases of glutathione in the tissues throughout the body. As a result, cells become more susceptible to stress.

Pro-oxidant shift in glutathione redox state during aging: Adv Drug Deliv Rev. 2008: 60(13-14): 1545-1552. Published online Jul 4, 2006

Glutathione in Human Plasma: Decline in Association With Aging, Age-related Macular Degeneration, and Diabetes: Free Radical Biology and Medicine, Vol. 24, No. 5, pp. 699-704, 1998

http://www.ncbi.nlm.nih.gov/pubmed/15936251

Arthritis and Glutathione

dataEntry — Wed, 22 Oct 2014 02:12:56 +0000

In joints, bones are prevented from rubbing against each other by cartilage; a soft tissue that covers the bones and allows the joints to work smoothly and painlessly, cartilage is housed inside the synovial membrane. Synovial fluid, also housed in the synovial membrane, lubricates and nourishes the joint and cartilage.

When arthritis occurs, something has happened to the joint’s health and function. They type of arthritis is determined by what part of the joint is affected and how. Lack of synovial fluid, cartilage deterioration, autoimmunity, inflammation, or a combination of factors can be causes of arthritis.

A powerful part of the body’s natural antioxidant system is a tri-peptide compound composed of cysteine, glycine and glutathione. Glutathione neutralizes free radicals and is needed for many metabolic processes among other important things.

It is necessary four our bodies to have optimal glutathione levels in order to support the immune system. As human’s age, the glutathione levels diminish and the glutathione antioxidant system weakens. This results in a less efficient immune system the more the body ages. Due to age related oxidative stress the cells in joints become more prone to osteoarthritis (OA) and other associated diseases.

Studies show that GSH could be applied in the managing of rheumatoid arthritis and osteoarthritis.

Rheumatoid Arthritis (RA)

dataEntry — Wed, 22 Oct 2014 00:44:38 +0000

Rheumatoid Arthritis is an inflammatory disease that affects the lining of the joints, which produces joint inflammation. Glutathione may help control the disease and alleviate the symptoms. Rheumatoid Arthritis progresses with age; glutathione neutralizes free radicals that lessen the damage to the muscles and tissues of the joints. Glutathione’s anti-inflammatory properties can help control joint... Read more »