Glutathione411 » Detoxification

Glutathione Detoxifies Harmful Substances in Cigarette Smoke

dataEntry — Thu, 30 Oct 2014 17:42:13 +0000

Glutathione is highly concentrated in the epithelial lining fluid of the lungs. It helps protect against inhaled oxidants. Glutathione’s response to cigarette smoke was examined in mice. After cigarette exposure, the levels of GSH were depleted by almost 50%. Glutathione adapted to the smoke by increasing its levels within the epithelial lining fluid.

Irritation from components of particulates in smoke cause oxidative stress. Chronic smokers increase their defenses from the smoke by increasing their glutathione levels in the epithelial lining fluid. The epithelial cells (lung cells) become overwhelmed due to the repeated cigarette smoke which leads to cell toxicity. Repeated inhalation of cigarette smoke results in smoking-induced lung disease.

http://www.gshnow.com/smoke_article.html

http://www.ncbi.nlm.nih.gov/pubmed/21982222

Age-related Decline in Immunity

dataEntry — Thu, 30 Oct 2014 02:50:12 +0000

Studies have shown that levels of GSH in the blood decrease with age. GSH functions as an antioxidant along with vitamins C and E to reduce levels of toxins in the blood and tissues. As we age, the levels of GSH decrease along with our ability to fight the diseases associated with aging. The attack of the toxins is often called “oxidative stress” and the lower levels of GSH in the blood and tissue reduce our ability to compensate for exposure to the free radicals. This decline is also associated with age related macular degeneration and diabetes. The generalized oxidation associated with aging may contribute to the development of age-related toxicities and pathology.

GSH serves several physiological functions. It quenches free radicals through direct interaction, helps to degrade harmful peroxides, and acts as a coenzyme. The main relevance of GSH to the aging process is that it provides important defense against oxidative stress, namely the reduction of hydrogen peroxide and lipid peroxides. GSH has the dual ability to quench free radical as well as donate electrons to essential cellular functions. It is regarded as the single most versatile antioxidant in cells with broad effects on antioxidant potential. It also maintains a buffer that is critical in most cellular processes including division and protein structure. An age-related loss of GSH can be predicted to have at least two dire consequences. One is the increase of levels of hydrogen peroxide and the second is the formation of molecules that interfere with enzymes in the body. This reduces the body’s ability to adapt under stress. Maintenance of optimal GSH levels in essential for limiting oxidative damage.

Wrinkles are a side effect of aging. Glutathione is a critical component for the body’s defense system. Glutathione provides protection for the cells against stress. Mild effects of stress stimulate glutathione levels, which increases the protection against more severe stress. Aging causes decreases of glutathione in the tissues throughout the body. As a result, cells become more susceptible to stress.

Pro-oxidant shift in glutathione redox state during aging: Adv Drug Deliv Rev. 2008: 60(13-14): 1545-1552. Published online Jul 4, 2006

Glutathione in Human Plasma: Decline in Association With Aging, Age-related Macular Degeneration, and Diabetes: Free Radical Biology and Medicine, Vol. 24, No. 5, pp. 699-704, 1998

http://www.ncbi.nlm.nih.gov/pubmed/15936251

Glutathione and Mercury Detoxification

dataEntry — Tue, 21 Oct 2014 17:08:08 +0000

Mercury poisoning is a type of heavy metal poisoning caused by exposure to mercury or its chemical compounds. Mercury occurs in several forms, all of which can produce toxic effects in high enough doses. In our industrialized world exposure to mercury happens every day. Common sources of mercury poisoning include mercury based dental fillings, seafood, vaccinations, and pollution from coal-burning power plants among many others. Mercury poisoning targets the liver, kidneys, brain, heart, lungs, pituitary and thyroid glands. Mercury poisoning also increases the risk of developing type 2 diabetes and has recently been implicated in the rising number of autistic cases. Specific symptoms of mercury toxicity usually include slurred speech, impaired hearing and vision, a lack of coordination, and general feeling of being unwell.

Research shows that the first step in effective mercury detoxification is boosting your glutathione levels. Glutathione binding to heavy metals has been shown to be a significant factor in heavy metal mobilization and excretion, specifically when applied to mercury and other heavy metals. Glutathione supplementation has also been shown to have specific effects on mercury toxicity by altering antioxidant status in the body.

http://www.ncbi.nlm.nih.gov/pubmed/24604198

http://www.ncbi.nlm.nih.gov/pubmed/24157516

http://www.glutathioneexperts.com/glutathione-heavy-metal-9.html