Glutathione411 » Liver Detox

Alcoholism and Glutathione Depletion

dataEntry — Thu, 30 Oct 2014 03:14:59 +0000

Alcoholism can cause damage to the lungs. The relationship between alcohol abuse and the lungs is indirect unlike the relationship between alcohol abuse and the liver. Lungs are dependent on glutathione for protection against oxidative damage. Chronic alcohol abuse causes glutathione levels to be depleted about 80-90% within the alveolar spaces. This dramatic decrease damages the production of the alveolar epithelial surfactant. The lungs start to become more susceptible to oxidative stress and further damage.

http://www.eurekalert.org/pub_releases/2002-04/euhs-gdi041902.php

http://www.ncbi.nlm.nih.gov/pubmed/?term=17220370

Glutathione and Mercury Detoxification

dataEntry — Tue, 21 Oct 2014 17:08:08 +0000

Mercury poisoning is a type of heavy metal poisoning caused by exposure to mercury or its chemical compounds. Mercury occurs in several forms, all of which can produce toxic effects in high enough doses. In our industrialized world exposure to mercury happens every day. Common sources of mercury poisoning include mercury based dental fillings, seafood, vaccinations, and pollution from coal-burning power plants among many others. Mercury poisoning targets the liver, kidneys, brain, heart, lungs, pituitary and thyroid glands. Mercury poisoning also increases the risk of developing type 2 diabetes and has recently been implicated in the rising number of autistic cases. Specific symptoms of mercury toxicity usually include slurred speech, impaired hearing and vision, a lack of coordination, and general feeling of being unwell.

Research shows that the first step in effective mercury detoxification is boosting your glutathione levels. Glutathione binding to heavy metals has been shown to be a significant factor in heavy metal mobilization and excretion, specifically when applied to mercury and other heavy metals. Glutathione supplementation has also been shown to have specific effects on mercury toxicity by altering antioxidant status in the body.

http://www.ncbi.nlm.nih.gov/pubmed/24604198

http://www.ncbi.nlm.nih.gov/pubmed/24157516

http://www.glutathioneexperts.com/glutathione-heavy-metal-9.html

Acetaminophen Poisoning and Glutathione

dataEntry — Tue, 21 Oct 2014 03:01:32 +0000

Tylenol (Acetaminophen) poisoning happens when someone takes more than the suggested dose. The recommended dose is 4000 mg daily. While considered safe in medicinal doses, at larger doses, acetaminophen can be fatal. Nearly half of all cases of acute liver failure in the United States and England can be attributed to acetaminophen poisoning.

Symptoms of acetaminophen poisoning may not present until 12 or more hours after the acetaminophen was ingested. Without early treatment, within the first 8 hours after the overdose, acetaminophen poisoning may lead to liver failure and death within 3 to 5 days.

Once the acetaminophen is ingested, a complex sequence of events begins which ultimately leads to liver failure. In the second step of this process the glutathione levels in the liver are completely depleted which allows for the formation of oxidative stress among other things.

Studies show that early treatment with GSH and its precursor N-acetylcysteine (NAC) can protect patients with acetaminophen poisoning against the overdose by raising the liver’s mitochondrial levels of GSH and providing support to the energy metabolism of the mitochondria.

http://www.ncbi.nlm.nih.gov/pubmed/1981532

http://www.nlm.nih.gov/medlineplus/ency/article/002598.html

http://www.ncbi.nlm.nih.gov/pubmed/19821517

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2836803/