Posts Categorized: Oxidative Stress

Glutathione’s Role in Pancreatitis

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Pancreatitis is a progressive inflammatory disease of the pancreas. The pancreas starts being digested by digestive enzymes. Lipid peroxidation increases due to enhanced amounts of oxygen radicals. Oxidative stress has a huge, negative impact on this disease. Glutathione is dramatically decreased due to oxidative stress. Glutathione can help control the activity of oxidative stress and… Read more »

Glutathione Detoxifies Harmful Substances in Cigarette Smoke

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Glutathione is highly concentrated in the epithelial lining fluid of the lungs. It helps protect against inhaled oxidants. Glutathione’s response to cigarette smoke was examined in mice. After cigarette exposure, the levels of GSH were depleted by almost 50%. Glutathione adapted to the smoke by increasing its levels within the epithelial lining fluid. Irritation from… Read more »

Glutathione a New Therapeutic Intervention for Crohn’s Disease

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Crohn’s Disease is an inflammatory condition of the gastrointestinal tract. Free radical production and nutritional depletion increase as the disease progresses. Reactive oxygen species cause tissue injury in Crohn’s Disease. Active enzymes and cysteine are critical for glutathione synthesis. Individuals with Crohn’s have low levels of enzymes and cysteine, resulting in a depletion of glutathione…. Read more »

Glutathione May Prevent Seizures

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Epilepsy is a chronic neurological disorder that causes abnormal brain function due to the characteristic of seizures. Seizures produce large amounts of oxidative stress. Oxidative stress causes damage to brain cells. Glutathione is a neuromodulator, meaning it affects the function of brain cells. Glutathione can help prevent seizures and the effects of anticonvulsants. Anticonvulsants can… Read more »

Glutathione Seems to Alleviate Symptoms of Depression

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Depression is characterized by severe emotional despondency and dejection felt over a period of time and accompanied by feelings of hopelessness and inadequacy. Common symptoms include difficulty with remembering things or making decisions, setting priorities, planning, and taking action. Free radical oxidative stress is one of the main causes of the mechanisms that contribute to… Read more »

Glutathione Treatment Affective on Bipolar Disorder

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Bipolar Disorder is associated with oxidative stress. Bipolar Disorder creates alterations in dopamine and glutamate, which are highly redox reactive. When both dopamine and glutamate are altered there is an increase in oxygen to the brain. Glutathione and other antioxidants are being researched further for a treatment, but an antioxidant precursor treatment is effective.  … Read more »

Glutathione may Have a Positive Affect on Lou Gehrig’s Disease

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Amyotrophic Lateral Sclerosis (ALS), commonly known as “Lou Gehrig’s Disease,” is a terminal, paralytic illness that affects nerve cells in the brain and spinal cord. Although ALS’s cause is currently unknown, recent studies implicate the affect of free radicals in the death and deterioration of motor neurons in this disease. The motor neuron’s death erodes… Read more »

Multiple Sclerosis (MS) and Glutathione

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Multiple Sclerosis is a chronic inflammatory disease of the nervous system. Multiple Sclerosis is multifactorial, but one major cause could be oxidative stress. Oxidative stress is a result from the imbalance of antioxidants and oxidants. In certain studies, glutathione was found low within the cerebrospinal fluid and blood in patients with Multiple Sclerosis.    … Read more »

Glutathione’s Role in Alzheimer’s

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Oxidative stress plays a key role in tissue damage within the brain. Brain tissue is more susceptible to free radical damage than other tissues throughout the body. GSH levels are low in the Hippocampus (short-term memory) and Cerebral Cortex (cognitive learning) of the brain. High levels of glutathione may help prevent the loss of ability… Read more »

Alcoholism and Glutathione Depletion

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Alcoholism can cause damage to the lungs. The relationship between alcohol abuse and the lungs is indirect unlike the relationship between alcohol abuse and the liver. Lungs are dependent on glutathione for protection against oxidative damage. Chronic alcohol abuse causes glutathione levels to be depleted about 80-90% within the alveolar spaces. This dramatic decrease damages… Read more »