Glutathione411 » Oxidative Stress

Glutathione’s Role in Pancreatitis

dataEntry — Thu, 30 Oct 2014 17:49:14 +0000

Pancreatitis is a progressive inflammatory disease of the pancreas. The pancreas starts being digested by digestive enzymes. Lipid peroxidation increases due to enhanced amounts of oxygen radicals. Oxidative stress has a huge, negative impact on this disease. Glutathione is dramatically decreased due to oxidative stress. Glutathione can help control the activity of oxidative stress and... Read more »

Glutathione Detoxifies Harmful Substances in Cigarette Smoke

dataEntry — Thu, 30 Oct 2014 17:42:13 +0000

Glutathione is highly concentrated in the epithelial lining fluid of the lungs. It helps protect against inhaled oxidants. Glutathione’s response to cigarette smoke was examined in mice. After cigarette exposure, the levels of GSH were depleted by almost 50%. Glutathione adapted to the smoke by increasing its levels within the epithelial lining fluid.

Irritation from components of particulates in smoke cause oxidative stress. Chronic smokers increase their defenses from the smoke by increasing their glutathione levels in the epithelial lining fluid. The epithelial cells (lung cells) become overwhelmed due to the repeated cigarette smoke which leads to cell toxicity. Repeated inhalation of cigarette smoke results in smoking-induced lung disease.

http://www.gshnow.com/smoke_article.html

http://www.ncbi.nlm.nih.gov/pubmed/21982222

Glutathione a New Therapeutic Intervention for Crohn’s Disease

dataEntry — Thu, 30 Oct 2014 17:38:07 +0000

Crohn’s Disease is an inflammatory condition of the gastrointestinal tract. Free radical production and nutritional depletion increase as the disease progresses. Reactive oxygen species cause tissue injury in Crohn’s Disease. Active enzymes and cysteine are critical for glutathione synthesis. Individuals with Crohn’s have low levels of enzymes and cysteine, resulting in a depletion of glutathione. When glutathione is depleted oxidative stress increases. Glutathione is starting to become the target for a therapeutic intervention for people who are suffering with Crohn’s Disease.

http://www.ncbi.nlm.nih.gov/pubmed/?term=10601540

http://www.ncbi.nlm.nih.gov/pubmed/?term=PMC1727080

Glutathione May Prevent Seizures

dataEntry — Thu, 30 Oct 2014 04:30:10 +0000

Epilepsy is a chronic neurological disorder that causes abnormal brain function due to the characteristic of seizures. Seizures produce large amounts of oxidative stress. Oxidative stress causes damage to brain cells. Glutathione is a neuromodulator, meaning it affects the function of brain cells. Glutathione can help prevent seizures and the effects of anticonvulsants. Anticonvulsants can lower the levels of glutathione within the brain, which allows for more oxidative stress.

http://www.ncbi.nlm.nih.gov/pubmed/?term=10876010

Glutathione Seems to Alleviate Symptoms of Depression

dataEntry — Thu, 30 Oct 2014 04:14:43 +0000

Depression is characterized by severe emotional despondency and dejection felt over a period of time and accompanied by feelings of hopelessness and inadequacy. Common symptoms include difficulty with remembering things or making decisions, setting priorities, planning, and taking action. Free radical oxidative stress is one of the main causes of the mechanisms that contribute to depression. Glutathione is a new way to treat the condition. The results of a clinical trial published in a 2008 issue of “Biological Psychiatry” showed that taking 1 gram of N-acetyl cysteine as a supplement twice daily for 24 weeks increases glutathione levels in the body and helped alleviate depressive symptoms.

http://www.ncbi.nlm.nih.gov/pubmed/18534556

Glutathione Treatment Affective on Bipolar Disorder

dataEntry — Thu, 30 Oct 2014 04:11:09 +0000

Bipolar Disorder is associated with oxidative stress. Bipolar Disorder creates alterations in dopamine and glutamate, which are highly redox reactive. When both dopamine and glutamate are altered there is an increase in oxygen to the brain. Glutathione and other antioxidants are being researched further for a treatment, but an antioxidant precursor treatment is effective. ... Read more »

Glutathione may Have a Positive Affect on Lou Gehrig’s Disease

dataEntry — Thu, 30 Oct 2014 04:05:16 +0000

Amyotrophic Lateral Sclerosis (ALS), commonly known as “Lou Gehrig’s Disease,” is a terminal, paralytic illness that affects nerve cells in the brain and spinal cord. Although ALS’s cause is currently unknown, recent studies implicate the affect of free radicals in the death and deterioration of motor neurons in this disease. The motor neuron’s death erodes the brain’s ability to initiate and control muscle movements. It is not uncommon to see advanced ALS patients completely paralyzed.

Studies further indicate that glutathione activity is greatly reduced in the parts of the brain that are affected by ALS. These findings suggest that glutathione levels and free radicals may be involved in the evolution and manifestation of the disease. Research shows that raising the levels of glutathione in ALS patients may help prevent cellular damage by free radicals.

http://www.alsa.org/about-als/what-is-als.html

http://www.ncbi.nlm.nih.gov/pubmed/8967746

Multiple Sclerosis (MS) and Glutathione

dataEntry — Thu, 30 Oct 2014 03:47:32 +0000

Multiple Sclerosis is a chronic inflammatory disease of the nervous system. Multiple Sclerosis is multifactorial, but one major cause could be oxidative stress. Oxidative stress is a result from the imbalance of antioxidants and oxidants. In certain studies, glutathione was found low within the cerebrospinal fluid and blood in patients with Multiple Sclerosis. ... Read more »

Glutathione’s Role in Alzheimer’s

dataEntry — Thu, 30 Oct 2014 03:33:16 +0000

Oxidative stress plays a key role in tissue damage within the brain. Brain tissue is more susceptible to free radical damage than other tissues throughout the body. GSH levels are low in the Hippocampus (short-term memory) and Cerebral Cortex (cognitive learning) of the brain. High levels of glutathione may help prevent the loss of ability... Read more »

Alcoholism and Glutathione Depletion

dataEntry — Thu, 30 Oct 2014 03:14:59 +0000

Alcoholism can cause damage to the lungs. The relationship between alcohol abuse and the lungs is indirect unlike the relationship between alcohol abuse and the liver. Lungs are dependent on glutathione for protection against oxidative damage. Chronic alcohol abuse causes glutathione levels to be depleted about 80-90% within the alveolar spaces. This dramatic decrease damages the production of the alveolar epithelial surfactant. The lungs start to become more susceptible to oxidative stress and further damage.

http://www.eurekalert.org/pub_releases/2002-04/euhs-gdi041902.php

http://www.ncbi.nlm.nih.gov/pubmed/?term=17220370