Glutathione411 » Preventative

Glutathione’s Role in Pancreatitis

dataEntry — Thu, 30 Oct 2014 17:49:14 +0000

Pancreatitis is a progressive inflammatory disease of the pancreas. The pancreas starts being digested by digestive enzymes. Lipid peroxidation increases due to enhanced amounts of oxygen radicals. Oxidative stress has a huge, negative impact on this disease. Glutathione is dramatically decreased due to oxidative stress. Glutathione can help control the activity of oxidative stress and... Read more »

Glutathione May Prevent Seizures

dataEntry — Thu, 30 Oct 2014 04:30:10 +0000

Epilepsy is a chronic neurological disorder that causes abnormal brain function due to the characteristic of seizures. Seizures produce large amounts of oxidative stress. Oxidative stress causes damage to brain cells. Glutathione is a neuromodulator, meaning it affects the function of brain cells. Glutathione can help prevent seizures and the effects of anticonvulsants. Anticonvulsants can lower the levels of glutathione within the brain, which allows for more oxidative stress.

http://www.ncbi.nlm.nih.gov/pubmed/?term=10876010

Glutathione’s Role in Alzheimer’s

dataEntry — Thu, 30 Oct 2014 03:33:16 +0000

Oxidative stress plays a key role in tissue damage within the brain. Brain tissue is more susceptible to free radical damage than other tissues throughout the body. GSH levels are low in the Hippocampus (short-term memory) and Cerebral Cortex (cognitive learning) of the brain. High levels of glutathione may help prevent the loss of ability... Read more »

Glutathione and Male-Pattern Baldness

dataEntry — Tue, 21 Oct 2014 17:03:04 +0000

Male-Pattern Baldness is a hereditary condition triggered by specific sex hormones (androgens) that cause a pattern of permanent hair loss. More common in men, thinning hair can begin as early as puberty. In male-pattern baldness androgens target hair follicles, converting them into stronger hormones. The result is hair growth slowing or stopping completely.

Research shows that the conversion of these hormones can be influenced by glutathione, suggesting that GSH plays a protective role and helps maintain the hair growth cycle.

http://www.ncbi.nlm.nih.gov/pubmed/8757755

Amyotrophic Lateral Sclerosis (ALS), “Lou Gehrig’s Disease” and Glutathione

dataEntry — Tue, 21 Oct 2014 16:35:19 +0000

Amyotrophic Lateral Sclerosis (ALS), commonly known as “Lou Gehrig’s Disease,” is a terminal, paralytic illness that affects nerve cells in the brain and spinal cord. Although ALS’s cause is currently unknown, recent studies implicate the affect of free radicals in the death and deterioration of motor neurons caused by this disease. The motor neuron’s death erodes the brain’s ability to initiate and control muscle movements. It is not uncommon to see advanced ALS patients completely paralyzed.

Studies further indicate that glutathione activity is greatly reduced in the parts of the brain that are affected by ALS. These findings suggest that glutathione levels and free radicals may be involved in the evolution and manifestation of the disease.

Research shows that raising the levels of glutathione in ALS patients may help prevent cellular damage by free radicals.

http://www.alsa.org/about-als/what-is-als.html
http://www.ncbi.nlm.nih.gov/pubmed/8967746

Acetaminophen Poisoning and Glutathione

dataEntry — Tue, 21 Oct 2014 03:01:32 +0000

Tylenol (Acetaminophen) poisoning happens when someone takes more than the suggested dose. The recommended dose is 4000 mg daily. While considered safe in medicinal doses, at larger doses, acetaminophen can be fatal. Nearly half of all cases of acute liver failure in the United States and England can be attributed to acetaminophen poisoning.

Symptoms of acetaminophen poisoning may not present until 12 or more hours after the acetaminophen was ingested. Without early treatment, within the first 8 hours after the overdose, acetaminophen poisoning may lead to liver failure and death within 3 to 5 days.

Once the acetaminophen is ingested, a complex sequence of events begins which ultimately leads to liver failure. In the second step of this process the glutathione levels in the liver are completely depleted which allows for the formation of oxidative stress among other things.

Studies show that early treatment with GSH and its precursor N-acetylcysteine (NAC) can protect patients with acetaminophen poisoning against the overdose by raising the liver’s mitochondrial levels of GSH and providing support to the energy metabolism of the mitochondria.

http://www.ncbi.nlm.nih.gov/pubmed/1981532

http://www.nlm.nih.gov/medlineplus/ency/article/002598.html

http://www.ncbi.nlm.nih.gov/pubmed/19821517

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2836803/

Diabetic Neuropathy (DN) and Glutathione

dataEntry — Sun, 19 Oct 2014 02:51:03 +0000

Diabetes and its compilations are caused by many factors. Antioxidant substances can be used to protect the body’s naturally occurring neurons. When used as an antioxidant enzyme, glutathione protects tissues from the oxidative damage experienced in Type 1 diabetes and it’s complications.

Diabetic Neuropathy (DN) is a secondary complication of diabetes that specifically attacks the nerves. Symptoms may include impaired senses and extreme pain.

Studies show that when diabetic patients were supplemented with glutathione neurological changes were prevented. Researchers conclude that glutathione supplementation provides a stronger neuroprotective affect that than glutamine and significantly reduces oxidative stress. Glutathione supplementation may prohibit the development of DN.

http://www.ncbi.nlm.nih.gov/pubmed/24370785

http://www.ncbi.nlm.nih.gov/pubmed/23021798

http://www.ncbi.nlm.nih.gov/pubmed/25176371